A soybean replicated trial in east-central Iowa, during a hot and dry season, revealed that two varients of Vitazyme and an amino acid formulation, alone or together, all raised bean yield by 6 to 7%; all increases were significant, except for the Vitazyme 2 treatment, which was nearly so. Test weight and protein were not influenced significantly by the treatments. These results show the great efficacy of utilizing these materials for Corn Belt soybean production, since at $16.00/bu (the fall 2012 soybean price) a 3.62 bu/acre increase for Vitazyme 1 equals $57.92/acre greater income.